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KMID : 0613820060160020357
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Journal of Life Science
2006 Volume.16 No. 2 p.357 ~ p.359
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Studies on Fibrinolytic Activity of Jujube ( Zizyphus mauritiana) Extract
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Lee Min-Kyung
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Abstract
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Crude extract prepared from jujube (Zizyphus mauritiana) possseses fibrinolytic activity hydrolyzing fibrin. A clear transparent region is observed where fibrin is hydrolyzed, and its diameter increased as the added jujube extract increased. The fibrinolytic activity of jujube extract seems to be heat and acid stable since its activity was retained after heat treatment at 100℃ for 10 min or an acid treatment by incubating at pH 2.0, 3.0, and 4.0 for 3 hours. But the jujube extract dialyzed with a cellulose membrane with molecular weight cutoff of 12,000 and 2,000 lost its activity, which suggests the fibrinolytic activity might be compounds of low molecular weight.
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KEYWORD
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Jujube extract, fibrinolytic activity, stability
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